NRGBiotic™
Study Site:
The University of Queensland Mayne Medical School 288 Herston Road, Herston Brisbane, QLD, 4006 AustraliaFormulation:
- A daily dose of 2 x probiotic capsules. Each capsule contains 50 billion colony-forming units (CFU) of live organisms (Lactobacillus acidophilus +Lactobacillus casei +Lactobacillus rhamnosus JB-1.). the probiotic will be taken in addition to a prescribed dose of SSRI medication for participants with a demonstrated history of chronic treatment resistant depression.
- A daily dose of 1600mg of Orotic acid in the magnesium orotate form. Magnesium orotate will be taken in addition to a prescribed dose of SSRI medication for participants with a demonstrated history of chronic treatment resistant depression.
About Trial:
A Phase I safety and exploratory end-point trial investigating the role of Probiotics and Magnesium Orotate [NRGBiotic™] co-administered with Antidepressant Medications for the Management of Treatment Resistant Depression
Prior trials:
NRGBiotic™ [Pilot 1] A randomised placebo-controlled clinical trial investigating the role of a combination of probiotics and magnesium orotate for the management of depression.
Date started: 13/02/2017
HREC name: QUT Office of Research Ethics and Integrity / The University Of Queensland Institutional Human Research Ethics Committee A.
HREC Approval ID: / 2017000186
CTN: CT- CT-2017-CTN-01080-1 v3
ANZCTR: ACTRN12617000419369
Study site: Queensland University of Technology, 2 George Street, Brisbane City, QLD, 4000.
Magnesium Orotate: The effect of 1600mg daily dosage of Magnesium supplementation as an augment to SSRI medication on the clinical symptoms of patients with treatment-resistant depression: a pilot study.
Date started: 21/04/2014
HREC Name: Behavioural & Social Sciences Ethical Review Committee (BSSERC) and Medical Research Ethics Committee (MREC)University of Queensland.
HREC Approval ID: 2012000647
AZNCTR: ACTRN12614000574640
Study site: Royal Brisbane and Women’s Hospital – Department of Psychiatry
HREC Date:
2014-03-21HREC Date:
2014-03-21HREC ID:
2012000647PUBLICATIONS OR CONFERENCES ASSOCIATED WITH THE PROGRAM
Inflammopharmacology. 2017 Feb 2. doi: 10.1007/s10787-017-0311-x
Date: 2017-04-25
Authors: Bambling M, Edwards SC, Hall S, Vitetta L
Advances in Integrative Medicine. 2015, 2(1):56-62
Date: 2015-04-01
Authors: Bambling M, Edwards SC, Coulson S, Vitetta L
General Practice Conference and Exhibition [Sydney, Melbourne] 2015
Date: 2015-01-01
Authors: Vitetta L, Coulson S
BIT’s 14th Annual Congress of IDDST June 16-18, 2016. South Korea
Date: 2016-06-16
Authors: Hall S
Australas Psychiatry. 2016;24(5):466-469.
Date: 2016-10-01
Authors: Liu X, Furuya-Kanamori L, Siskind D, Crompton D, Williams GM, Kostner K, Vitetta L, Doi SA
J Cell Biochem. 2020 Jan;121(1):17-24. doi: 10.1002/jcb.29311. Epub 2019 Aug 5.PMID: 31385365
Date: 2020-01-01
Authors: Chen J, Vitetta L
PARTNER'S ASSOCIATED WITH THE PROGRAM
The University of Queensland
The University of Queensland is a public research university located primarily in Brisbane, the capital city of the Australian state of Queensland. This world-leading university was founded in 1909 by the state parliament and ranked equal second in Australia.
As of July 2020, it had over 54,000 students and 2,900+ academic staff.
For more information about The University of Queensland visit https://www.uq.edu.au/about/university-profile
